2019 marks 100 years since the establishment of the Sir John and Lady Eaton Professor and Chair of Medicine, an endowment that has had a transformative impact on the Department and broader Faculty of Medicine at University of Toronto. Former Department Chairs Arnie Aberman, Eliott Phillipson, Wendy Levinson and Gillian Hawker reflect on this momentous anniversary, and the legacy and impact of the Department of Medicine today.